Sespe Health Holdings

Permanent capital purpose-built for healthcare

Our Philosophy

We understand that many of the largest and most innovative healthcare companies scaled steadily in early innings, and have built our firm to support this period of growth and beyond.

Sespe Health partners early with proven management teams to build enduring, impactful, innovative healthcare companies.  We believe differentiation in our industry starts with patience and combines an opinionated go-to-market strategy, targeted technology enablement and deliberate execution. We are experienced healthcare operators and investors with an owner mentality and a founder's comfort for early-stage risk.  

Our permanent capital model allows for flexibility on investment structures, growth strategies, hold-times and exit pathways.  Our capital partners, many of whom are successful entrepreneurs themselves, are  long-term thinkers who know the time horizon for the right company could be eternity. We believe this flexible approach best aligns with founders and management teams executing a long-term vision in a complex industry.

If you are building in payer services, pharma services, or tech-enabled care delivery, and see the world as we do, please reach out.

Sander Duncan

Founder and Managing Partner
Sespe Health Holdings

We devote the majority of our resources toward a concentrated, long-term portfolio of Platform Partnerships. We also make smaller, opportunistic venture investments.

Platform Partnerships

Larger investments arising from substantial conviction in an end market or care model, and deep strategic and operational alignment with the founding team.

We partner early, prefer tenured leadership, underwrite to attainable outcomes, and are comfortable with light structure to ensure alignment with management and their plans for growth. Our Platform Partnerships have unlimited investment timelines .

Partnerships include:

Founded by Keith Passwater, formerly the Chief Actuary Officer for Anthem/Elevance, Havarti Risk is the leading platform supporting the next generation of risk bearing entities in U.S. healthcare.

Venture Investments

Smaller checks to support founders from Pre-Seed through Series B alongside institutional healthcare syndicates.  These investments often are opportunistic but always arise from a strong, existing relationship with the founder or lead investor. Certain Venture Investments could evolve to Platform Partnerships over time.

Whole-person in-home care for dual-eligible patients, treating and coordinating services for both health and social needs. 

Founded and seeded by serial healthcare entrepreneurs and enterprise executives with deep domain expertise.

Digital platform and care model that predicts, preempts and mitigates crises for the 14M Americans with serious mental illness (SMI). 

Founded by serial entrepeneurs and individuals with personal exposure to SMI.

Practice transformation software and services for General Practitioners and Orthodontists. 

Founded by executives who previously scaled Align Technologies.

Team-based, tech-enabled austism care offering fully-insured Developmental Relationsionship-Based Intervention (DRI) for children and their families. 

Founded by payer executives personally affected by special-needs family members.

We lean heavily on our network for thesis development, capital relationships, structuring guidance, and deep, long-term management team support.

The Sespe Network

Action-oriented, experienced and accessible

The foundation of Sespe Health is an active, growing network of pick-up-the-phone relationships with founders, CEOs, business development experts, investors, clinicians, technologists and policy makers from leading firms.

We value deep, genuine relationships with people we trust and admire. These folks are action-oriented, experienced, and accessible, and we proactively seek their input and guidance for ourselves and our management teams.